INS NYC 2024 Program

Poster	Poster Session 02 Program Schedule 02/15/2024 08:00 am - 09:15 am Room: Majestic Complex (Posters 61-120) Poster Session 02: Aging \| MCI \| Neurodegenerative Disease - PART 1 Final Abstract #88 Neuropsychiatric Symptoms and Everyday Functioning in the Prodromal Stage of Dementia with Lewy Bodies Ali Dadawalla, California State University, Fresno, Fresno, United States Abril Baez, California State University, Fresno, Fresno, United States Krithika Sivaramakrishnan, University of Florida, Gainesville, United States Austin Tran, University of California, Los Angeles, Los Angeles, United States Loren Alving, University of California, San Francisco, Fresno, United States David Lent, California State University, Fresno, Fresno, United States Matthew Wright, Lundquist Institute, Torrance, United States Jennifer Isom Schmidtke, California State University, Fresno, Fresno, United States Ellen Woo, California State University, Fresno, Fresno, United States Category: Dementia (Non-AD) Keyword 1: dementia with Lewy bodies Keyword 2: everyday functioning Objective: Neuropsychiatric symptoms (NPS) are commonly observed in individuals with dementia with Lewy bodies (DLB). Hallucinations, motor abnormalities, REM sleep behavior disorder, as well as attention and cognitive fluctuations, are hallmarks of DLB. Previous studies have indicated that apathy, depression, anxiety, and delusions are also associated with DLB. This study investigated the extent to which hallucinations, motor disturbances, nighttime behaviors, disinhibition, apathy, depression, anxiety, and delusions are predictive of everyday functioning in prodromal DLB. Participants and Methods: Participants included healthy older controls, (n=54), MCI with DLB etiology (n=214), and DLB (n=1045). All participants were eventually diagnosed with DLB upon later visits in the longitudinal study. The Neuropsychiatric Inventory Questionnaire (NPI-Q) and the Functional Activities Questionnaire (FAQ) data were administered. The FAQ was used to assess everyday functioning abilities through caregiver reports. Results: Multiple linear regressions were performed to assess the impact of NPS on total FAQ scores, with age being a covariate. The results indicated that apathy was predictive of everyday functioning in the control and MCI groups. Anxiety was also predictive of everyday functioning in the MCI group. Conclusions: Our findings indicated that some NPS, particularly apathy and anxiety, impacted everyday functioning in MCI participants who would eventually be diagnosed with DLB. These results suggest that assessing for apathy and anxiety in MCI may be useful for early identification and intervention in the earliest stages of DLB.

Poster

02/15/2024
08:00 am - 09:15 am
Room: Majestic Complex (Posters 61-120)

Poster Session 02: Aging | MCI | Neurodegenerative Disease - PART 1

Final Abstract #88

Neuropsychiatric Symptoms and Everyday Functioning in the Prodromal Stage of Dementia with Lewy Bodies

Ali Dadawalla, California State University, Fresno, Fresno, United States
Abril Baez, California State University, Fresno, Fresno, United States
Krithika Sivaramakrishnan, University of Florida, Gainesville, United States
Austin Tran, University of California, Los Angeles, Los Angeles, United States
Loren Alving, University of California, San Francisco, Fresno, United States
David Lent, California State University, Fresno, Fresno, United States
Matthew Wright, Lundquist Institute, Torrance, United States
Jennifer Isom Schmidtke, California State University, Fresno, Fresno, United States
Ellen Woo, California State University, Fresno, Fresno, United States

Category: Dementia (Non-AD)

Keyword 1: dementia with Lewy bodies
Keyword 2: everyday functioning

Objective:

Neuropsychiatric symptoms (NPS) are commonly observed in individuals with dementia with Lewy bodies (DLB). Hallucinations, motor abnormalities, REM sleep behavior disorder, as well as attention and cognitive fluctuations, are hallmarks of DLB. Previous studies have indicated that apathy, depression, anxiety, and delusions are also associated with DLB. This study investigated the extent to which hallucinations, motor disturbances, nighttime behaviors, disinhibition, apathy, depression, anxiety, and delusions are predictive of everyday functioning in prodromal DLB.

Participants and Methods:

Participants included healthy older controls, (n=54), MCI with DLB etiology (n=214), and DLB (n=1045). All participants were eventually diagnosed with DLB upon later visits in the longitudinal study. The Neuropsychiatric Inventory Questionnaire (NPI-Q) and the Functional Activities Questionnaire (FAQ) data were administered. The FAQ was used to assess everyday functioning abilities through caregiver reports.

Results:

Multiple linear regressions were performed to assess the impact of NPS on total FAQ scores, with age being a covariate. The results indicated that apathy was predictive of everyday functioning in the control and MCI groups. Anxiety was also predictive of everyday functioning in the MCI group.

Conclusions:

Our findings indicated that some NPS, particularly apathy and anxiety, impacted everyday functioning in MCI participants who would eventually be diagnosed with DLB. These results suggest that assessing for apathy and anxiety in MCI may be useful for early identification and intervention in the earliest stages of DLB.