INS NYC 2024 Program

Poster	Poster Session 02 Program Schedule 02/15/2024 08:00 am - 09:15 am Room: Shubert Complex (Posters 1-60) Poster Session 02: Aging \| MCI \| Neurodegenerative Disease - PART 1 Final Abstract #11 Are There Distinct Memory Impairment Patterns in Amnestic Mild Cognitive Impairment? Alicia Burgei, Michigan Alzheimer's Disease Research Center, Department of Neurology, University of Michigan Medical School, Ann Arbor, United States Subhamoy Pal, Michigan Alzheimer's Disease Research Center, Department of Neurology, University of Michigan Medical School, Ann Arbor, United States Jonathan Reader, Michigan Alzheimer's Disease Research Center, Department of Neurology, University of Michigan Medical School, Ann Arbor, United States Bruno Giordani, Michigan Alzheimer's Disease Research Center, Department of Neurology, University of Michigan Medical School, Ann Arbor, United States Category: MCI (Mild Cognitive Impairment) Keyword 1: assessment Keyword 2: working memory Keyword 3: aging disorders Objective: As the global population ages, the need for precise and sensitive diagnostic tools to identify cognitive impairment and age-related dementias becomes increasingly important. This study aims to identify the diagnostic distribution and severity of memory impairment in persons with amnestic Mild Cognitive Impairment (aMCI) during neuropsychological memory tasks. Specifically, the study seeks to differentiate between single-domain aMCI, characterized by isolated episodic memory impairments, and multiple-domain (aMCI+), which affects one or more cognitive areas of language, attention, executive function, or visuospatial abilities in addition to episodic memory impairments. Participants and Methods: Participants’ memory performances were compared across the two general categories of aMCI diagnosis (aMCI, aMCI+) as well as considering more specific cognitive deficit patterns. Participants (n = 210, age = 73.64 ± 8.22, 50% Black, 40% Male) with a first-time diagnosis of aMCI (converted from normal cognition during previous evaluation) were drawn from the longitudinal cohort of the Michigan Alzheimer’s Disease Research Center (MADRC). Participants were diagnosed via consensus conference with either aMCI (n = 73) or aMCI+ (n = 137) and completed both a paragraph learning Craft Story Recall 21 (CSR) and word-list learning Hopkins Verbal Learning Test (HVLT) as part of their annual Uniform Data Set Version 3 assessment. aMCI had significantly higher years of education compared to the aMCI+ group (15.57 ± 2.25 vs. 16.65 ± 2.56); thus, ANCOVAs were conducted to adjust for education when comparing memory score differences. Results: aMCI outperformed aMCI+ on CSR Immediate Recall (Paraphrase and Verbatim), CSR Delayed (Paraphrase only), and HVLT Immediate Recall T-Score (all p-values < 0.05) after adjusting for education. No significant difference was found on the HVLT Delayed Recall T-Score. Conclusions: As would be anticipated, the presence of additional areas of cognitive impairment contributed to reduced scores on memory performance measures. The lack of significant difference in the HVLT delayed recall may be attributed to the sensitivity of the assessment to memory impairment in both groups. Additional analysis of specific domains of cognitive impairment with aMCI+ helps highlight cognitive areas that contribute to interference in learning and recall memory tasks. Future research should be aimed at further understanding the underlying mechanisms that contribute to the development of cognitive deficit patterns in aMCI+. The implications for tailoring neuropsychological assessments and interventions based on cognitive profiles could significantly impact clinical practice in addressing cognitive decline and dementias associated with aging.

Poster

02/15/2024
08:00 am - 09:15 am
Room: Shubert Complex (Posters 1-60)

Poster Session 02: Aging | MCI | Neurodegenerative Disease - PART 1

Final Abstract #11

Are There Distinct Memory Impairment Patterns in Amnestic Mild Cognitive Impairment?

Alicia Burgei, Michigan Alzheimer's Disease Research Center, Department of Neurology, University of Michigan Medical School, Ann Arbor, United States
Subhamoy Pal, Michigan Alzheimer's Disease Research Center, Department of Neurology, University of Michigan Medical School, Ann Arbor, United States
Jonathan Reader, Michigan Alzheimer's Disease Research Center, Department of Neurology, University of Michigan Medical School, Ann Arbor, United States
Bruno Giordani, Michigan Alzheimer's Disease Research Center, Department of Neurology, University of Michigan Medical School, Ann Arbor, United States

Category: MCI (Mild Cognitive Impairment)

Keyword 1: assessment
Keyword 2: working memory
Keyword 3: aging disorders

Objective:

As the global population ages, the need for precise and sensitive diagnostic tools to identify cognitive impairment and age-related dementias becomes increasingly important. This study aims to identify the diagnostic distribution and severity of memory impairment in persons with amnestic Mild Cognitive Impairment (aMCI) during neuropsychological memory tasks. Specifically, the study seeks to differentiate between single-domain aMCI, characterized by isolated episodic memory impairments, and multiple-domain (aMCI+), which affects one or more cognitive areas of language, attention, executive function, or visuospatial abilities in addition to episodic memory impairments.

Participants and Methods:

Participants’ memory performances were compared across the two general categories of aMCI diagnosis (aMCI, aMCI+) as well as considering more specific cognitive deficit patterns. Participants (n = 210, age = 73.64 ± 8.22, 50% Black, 40% Male) with a first-time diagnosis of aMCI (converted from normal cognition during previous evaluation) were drawn from the longitudinal cohort of the Michigan Alzheimer’s Disease Research Center (MADRC). Participants were diagnosed via consensus conference with either aMCI (n = 73) or aMCI+ (n = 137) and completed both a paragraph learning Craft Story Recall 21 (CSR) and word-list learning Hopkins Verbal Learning Test (HVLT) as part of their annual Uniform Data Set Version 3 assessment. aMCI had significantly higher years of education compared to the aMCI+ group (15.57 ± 2.25 vs. 16.65 ± 2.56); thus, ANCOVAs were conducted to adjust for education when comparing memory score differences.

Results:

aMCI outperformed aMCI+ on CSR Immediate Recall (Paraphrase and Verbatim), CSR Delayed (Paraphrase only), and HVLT Immediate Recall T-Score (all p-values < 0.05) after adjusting for education. No significant difference was found on the HVLT Delayed Recall T-Score.

Conclusions:

As would be anticipated, the presence of additional areas of cognitive impairment contributed to reduced scores on memory performance measures. The lack of significant difference in the HVLT delayed recall may be attributed to the sensitivity of the assessment to memory impairment in both groups. Additional analysis of specific domains of cognitive impairment with aMCI+ helps highlight cognitive areas that contribute to interference in learning and recall memory tasks. Future research should be aimed at further understanding the underlying mechanisms that contribute to the development of cognitive deficit patterns in aMCI+. The implications for tailoring neuropsychological assessments and interventions based on cognitive profiles could significantly impact clinical practice in addressing cognitive decline and dementias associated with aging.