INS NYC 2024 Program

Symposium	Symposia 15 Program Schedule 02/17/2024 10:45 am - 12:10 pm Room: Broadway Ballroom Symposia 15: Risk Factors for Cognitive Decline Among Representative Samples: Baseline Findings from the U.S. POINTER Study Simposium #4 Relationship between subjective cognitive concern and engagement in physical, cognitive and social activity in the U.S. POINTER Study Bonnie Sachs, Wake Forest School of Medicine, Winston Salem, United States Laura Baker, Wake Forest School of Medicine, Winston Salem, United States Brad Caudle, Wake Forest School of Medicine, Winston Salem, United States Sarah Farias, UC Davis, Davis, United States Jeffrey Katula, Wake Forest University, Winston Salem, United States Athene Lee, Brown University, Providence, United States Laura Lovato, Wake Forest School of Medicine, Winston Salem, United States Heather Snyder, Alzheimer's Association, Chicago, United States Amber Thro, Wake Forest School of Medicine, Winston Salem, United States Kathryn Papp, Harvard University, Boston, United States Category: MCI (Mild Cognitive Impairment) Keyword 1: clinical trials Objective: There has been little investigation into the relationship between physical, cognitive, and social activity and subjective concern about cognition (SCD) in the absence of objective cognitive decline. This concern about subjective change is an important concept in the field of Alzheimer’s disease as it independently confers risk for developing MCI/AD. However, the exact relationship between SCD and engagement in positive daily activities is poorly understood. This project examines the relationship between SCD and self-reported engagement in these activities. Participants and Methods: U.S. POINTER is a phase 3, multicenter, 2-year randomized controlled trial of two lifestyle interventions varying in intensity and format, conducted in older adults living in the U.S. who do not have objective cognitive impairment at study entry, but have increased risk of cognitive decline and dementia. Participants completed myriad measures at baseline, including the Cognitive Function Inventory (CFI) assessing subjective cognitive decline, and the Community Healthy Activities Model Program for Seniors (CHAMPS) which assesses self-reported engagement in social, cognitive, and physical activities over the past 4 weeks. Results: Baseline study characteristics of the sample (N= 2101) are: Mean age=68.2y (5.1), 68.9% female, 30.0% with less than 16 years education, and 30.7% from underrepresented groups (URG). In separate multivariate linear models, high CFI scores were associated with lower weekly caloric expenditure in exercise (p< .01) and less frequent engagement in cognitive activity (p <.01). Higher CFI scores also tended to be associated with lower social engagement (p=.05). When examining sex as a factor in the model, the high levels of concern on the CFI were associated with lower levels of cognitive and social activities in women (p= <.001; .01 respectively) but not in men. The CFI-cognitive activity relationship was significant for URG participants (p=.01) but not White participants. There were no significant relationships between amyloid or tau biomarkers and CFI, or CHAMPS scores (all p’s >.05). Conclusions: In sum, SCD and engagement in physical, cognitive, and social activities are inversely related to varying degrees, such that individuals who report lower levels of engagement in these activities report more subjective cognitive concerns. However, different patterns emerged for some subgroups. Additional modeling is needed to demonstrate the directionality of the relationships between these activities and CFI, and the relationship with demographic variables of interest.

Symposium

02/17/2024
10:45 am - 12:10 pm
Room: Broadway Ballroom

Symposia 15: Risk Factors for Cognitive Decline Among Representative Samples: Baseline Findings from the U.S. POINTER Study

Simposium #4

Relationship between subjective cognitive concern and engagement in physical, cognitive and social activity in the U.S. POINTER Study

Bonnie Sachs, Wake Forest School of Medicine, Winston Salem, United States
Laura Baker, Wake Forest School of Medicine, Winston Salem, United States
Brad Caudle, Wake Forest School of Medicine, Winston Salem, United States
Sarah Farias, UC Davis, Davis, United States
Jeffrey Katula, Wake Forest University, Winston Salem, United States
Athene Lee, Brown University, Providence, United States
Laura Lovato, Wake Forest School of Medicine, Winston Salem, United States
Heather Snyder, Alzheimer's Association, Chicago, United States
Amber Thro, Wake Forest School of Medicine, Winston Salem, United States
Kathryn Papp, Harvard University, Boston, United States

Category: MCI (Mild Cognitive Impairment)

Keyword 1: clinical trials

Objective:

There has been little investigation into the relationship between physical, cognitive, and social activity and subjective concern about cognition (SCD) in the absence of objective cognitive decline. This concern about subjective change is an important concept in the field of Alzheimer’s disease as it independently confers risk for developing MCI/AD. However, the exact relationship between SCD and engagement in positive daily activities is poorly understood. This project examines the relationship between SCD and self-reported engagement in these activities.

Participants and Methods:

U.S. POINTER is a phase 3, multicenter, 2-year randomized controlled trial of two lifestyle interventions varying in intensity and format, conducted in older adults living in the U.S. who do not have objective cognitive impairment at study entry, but have increased risk of cognitive decline and dementia. Participants completed myriad measures at baseline, including the Cognitive Function Inventory (CFI) assessing subjective cognitive decline, and the Community Healthy Activities Model Program for Seniors (CHAMPS) which assesses self-reported engagement in social, cognitive, and physical activities over the past 4 weeks.

Results:

Baseline study characteristics of the sample (N= 2101) are: Mean age=68.2y (5.1), 68.9% female, 30.0% with less than 16 years education, and 30.7% from underrepresented groups (URG).

In separate multivariate linear models, high CFI scores were associated with lower weekly caloric expenditure in exercise (p< .01) and less frequent engagement in cognitive activity (p <.01). Higher CFI scores also tended to be associated with lower social engagement (p=.05). When examining sex as a factor in the model, the high levels of concern on the CFI were associated with lower levels of cognitive and social activities in women (p= <.001; .01 respectively) but not in men. The CFI-cognitive activity relationship was significant for URG participants (p=.01) but not White participants. There were no significant relationships between amyloid or tau biomarkers and CFI, or CHAMPS scores (all p’s >.05).

Conclusions:

In sum, SCD and engagement in physical, cognitive, and social activities are inversely related to varying degrees, such that individuals who report lower levels of engagement in these activities report more subjective cognitive concerns. However, different patterns emerged for some subgroups. Additional modeling is needed to demonstrate the directionality of the relationships between these activities and CFI, and the relationship with demographic variables of interest.