INS NYC 2024 Program

Speaker Portal Presentations	Program Schedule 02/17/2024 07:20 am - 08:50 am Room: West Side Ballroom - Salon 4 CE Workshop 12 Session Host Name: Sam J Crowley Host's Role: Introduction Leveraging Non-invasive Brain Stimulation for Neuropsychology Research: Transcranial Magnetic Stimulation for Remediating Disordered Cognition and Emotion Summary Abstract: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation method using pulses of electromagnetic stimulation applied to superficial cortical regions to activate or inhibit underlying brain regions such as the dorsolateral prefrontal cortex (DLPFC). For example, with repeated stimulation sessions over the DLPFC, rTMS has been shown to remediate numerous transdiagnostic impairments and is FDA approved for refractory depression, obsessive-compulsive disorder, and smoking cessation. In the case of neuropsychology research, the application of rTMS is still an emerging technique but has shown promise in remediating cognitive and affective impairments in a range of conditions including mild to moderate cognitive impairment, dementia, Alzheimer’s and Parkinson’s Diseases. Importantly, rTMS can be tailored to almost any cognitive-affective impairment for which the network substrates could be accessed via connections to superficial cortical nodes. As such, the possibilities for personalizing treatment are vast. Not surprisingly, new and promising indications emerge daily. In this workshop I will review the different types of rTMS and the ways in which these have been utilized in neuropsychology research. I will begin with a review of the basic mechanisms of rTMS, followed by trial design considerations including variations in pulse patterns, sham control, dosing, and targeting heuristics as well as outcomes in behavioral and imaging measures. Special emphasis will be placed on reviewing safety and consensus-based guidelines for best practice. I will also discuss the advantages as well as disadvantages of rTMS in relation to other forms of non-invasive brain stimulation. Number of Credit Hours: 1.5 Level of Instruction: Intermediate Learning Objectives: 1. Describe 3 different types of rTMS pulse patterns and how they affect targeted brain regions. 2. Identify the most common and significant safety concerns with rTMS. 3. Critically evaluate recent clinical trials of rTMS in neuropsychology in terms of dosing schedules. Presenter(s): Lisa M McTeague, PhD Medical Univeristy of South Carolina Dr. McTeague a licensed clinical psychologist and an Associate Professor in the Department of Psychiatry and Behavioral Sciences at Medical University of South Carolina where she serves as the Associate Director of the Brain Stimulation Division. She is also a practicing psychologist in the PTSD Clinical Team at the Ralph H. Johnson VA Health Care System. Her work in cognitive and affective neuroscience has consistently been transdiagnostic, examining neurobehavioral phenotypes (e.g., EEG, MRI, self-report) of emotional and cognitive dysfunction within but also between neuropsychiatric (i.e., PTSD, depression, substance use disorders) and neurodegenerative disorders (MCI, VCI). She has consistently observed that across disorders, emotional and cognitive impairment is related to disruptions in the neurocircuits that support intact or adaptive emotion and cognition. As such, she has utilized these findings as a roadmap for non-invasive brain stimulation, including rTMS as well as taVNS, TNS, tDCS, and focused ultrasound. Her work has a particular focus on examining targeting and dosing considerations in non-invasive brain stimulation toward developing novel adjunctive treatments for the most promising behavioral interventions in neuropsychiatric and neurodegenerative conditions.

Speaker Portal Presentations

02/17/2024
07:20 am - 08:50 am
Room: West Side Ballroom - Salon 4

CE Workshop 12

Session Host Name: Sam J Crowley
Host's Role: Introduction

Leveraging Non-invasive Brain Stimulation for Neuropsychology Research: Transcranial Magnetic Stimulation for Remediating Disordered Cognition and Emotion

Summary Abstract:

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation method using pulses of electromagnetic stimulation applied to superficial cortical regions to activate or inhibit underlying brain regions such as the dorsolateral prefrontal cortex (DLPFC). For example, with repeated stimulation sessions over the DLPFC, rTMS has been shown to remediate numerous transdiagnostic impairments and is FDA approved for refractory depression, obsessive-compulsive disorder, and smoking cessation. In the case of neuropsychology research, the application of rTMS is still an emerging technique but has shown promise in remediating cognitive and affective impairments in a range of conditions including mild to moderate cognitive impairment, dementia, Alzheimer’s and Parkinson’s Diseases. Importantly, rTMS can be tailored to almost any cognitive-affective impairment for which the network substrates could be accessed via connections to superficial cortical nodes. As such, the possibilities for personalizing treatment are vast. Not surprisingly, new and promising indications emerge daily.

In this workshop I will review the different types of rTMS and the ways in which these have been utilized in neuropsychology research. I will begin with a review of the basic mechanisms of rTMS, followed by trial design considerations including variations in pulse patterns, sham control, dosing, and targeting heuristics as well as outcomes in behavioral and imaging measures. Special emphasis will be placed on reviewing safety and consensus-based guidelines for best practice. I will also discuss the advantages as well as disadvantages of rTMS in relation to other forms of non-invasive brain stimulation.

Number of Credit Hours: 1.5

Level of Instruction: Intermediate

Learning Objectives:
1. Describe 3 different types of rTMS pulse patterns and how they affect targeted brain regions.
2. Identify the most common and significant safety concerns with rTMS.
3. Critically evaluate recent clinical trials of rTMS in neuropsychology in terms of dosing schedules.

Presenter(s):

Lisa M McTeague, PhD

Medical Univeristy of South Carolina

Dr. McTeague a licensed clinical psychologist and an Associate Professor in the Department of Psychiatry and Behavioral Sciences at Medical University of South Carolina where she serves as the Associate Director of the Brain Stimulation Division. She is also a practicing psychologist in the PTSD Clinical Team at the Ralph H. Johnson VA Health Care System. Her work in cognitive and affective neuroscience has consistently been transdiagnostic, examining neurobehavioral phenotypes (e.g., EEG, MRI, self-report) of emotional and cognitive dysfunction within but also between neuropsychiatric (i.e., PTSD, depression, substance use disorders) and neurodegenerative disorders (MCI, VCI). She has consistently observed that across disorders, emotional and cognitive impairment is related to disruptions in the neurocircuits that support intact or adaptive emotion and cognition. As such, she has utilized these findings as a roadmap for non-invasive brain stimulation, including rTMS as well as taVNS, TNS, tDCS, and focused ultrasound. Her work has a particular focus on examining targeting and dosing considerations in non-invasive brain stimulation toward developing novel adjunctive treatments for the most promising behavioral interventions in neuropsychiatric and neurodegenerative conditions.